Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-09-04 | Marist | 0 | Georgetown | 0 | Cancelled | - | - |
| 2 | 2021-09-18 | Marist | 14 | Columbia | 37 | Final | L | -23 |
| 3 | 2021-09-25 | Bryant | 34 | Marist | 17 | Final | L | -17 |
| 4 | 2021-10-02 | Marist | 27 | Valparaiso | 24 | Final(OT) | W | 3 |
| 5 | 2021-10-09 | Stetson | 3 | Marist | 34 | Final | W | 31 |
| 6 | 2021-10-16 | Marist | 20 | Dayton | 17 | Final | W | 3 |
| 7 | 2021-10-23 | Morehead State | 27 | Marist | 24 | Final | L | -3 |
| 8 | 2021-10-30 | Marist | 7 | St. Thomas | 27 | Final | L | -20 |
| 9 | 2021-11-06 | Drake | 0 | Marist | 7 | Final | W | 7 |
| 10 | 2021-11-13 | Marist | 57 | Presbyterian | 32 | Final | W | 25 |
| 11 | 2021-11-20 | Butler | 28 | Marist | 21 | Final | L | -7 |