Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-09-04 | Warner | 14 | Stetson | 54 | Final | W | 40 |
| 2 | 2021-09-11 | Ave Maria | 16 | Stetson | 49 | Final | W | 33 |
| 3 | 2021-09-25 | Stetson | 0 | Princeton | 63 | Final | L | -63 |
| 4 | 2021-10-02 | Davidson | 35 | Stetson | 28 | Final | L | -7 |
| 5 | 2021-10-09 | Stetson | 3 | Marist | 34 | Final | L | -31 |
| 6 | 2021-10-16 | St. Thomas | 38 | Stetson | 7 | Final | L | -31 |
| 7 | 2021-10-30 | Stetson | 62 | Presbyterian | 14 | Final | W | 48 |
| 8 | 2021-11-06 | Dayton | 41 | Stetson | 13 | Final | L | -28 |
| 9 | 2021-11-13 | Stetson | 35 | Morehead State | 36 | Final | L | -1 |
| 10 | 2021-11-20 | San Diego | 41 | Stetson | 16 | Final | L | -25 |