Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-09-04 | Butler | 7 | Illinois State | 49 | Final | L | -42 |
| 2 | 2021-09-11 | DePauw | 24 | Butler | 49 | Final | W | 25 |
| 3 | 2021-09-18 | Butler | 77 | Taylor | 24 | Final | W | 53 |
| 4 | 2021-09-25 | Butler | 0 | St. Thomas | 36 | Final | L | -36 |
| 5 | 2021-10-02 | Drake | 6 | Butler | 3 | Final | L | -3 |
| 6 | 2021-10-09 | San Diego | 52 | Butler | 21 | Final | L | -31 |
| 7 | 2021-10-16 | Butler | 8 | Morehead State | 31 | Final | L | -23 |
| 8 | 2021-10-23 | Davidson | 49 | Butler | 35 | Final | L | -14 |
| 9 | 2021-10-30 | Butler | 31 | Dayton | 38 | Final | L | -7 |
| 10 | 2021-11-13 | Valparaiso | 47 | Butler | 3 | Final | L | -44 |
| 11 | 2021-11-20 | Butler | 28 | Marist | 21 | Final | W | 7 |