Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-09-04 | Marist | 0 | Georgetown | 0 | Cancelled | - | - |
| 2 | 2021-09-11 | Georgetown | 20 | Delaware State | 14 | Final(OT) | W | 6 |
| 3 | 2021-09-18 | Harvard | 44 | Georgetown | 9 | Final | L | -35 |
| 4 | 2021-09-25 | Georgetown | 24 | Columbia | 35 | Final | L | -11 |
| 5 | 2021-10-02 | Colgate | 28 | Georgetown | 21 | Final | L | -7 |
| 6 | 2021-10-16 | Georgetown | 14 | Holy Cross | 48 | Final | L | -34 |
| 7 | 2021-10-23 | Georgetown | 29 | Bucknell | 21 | Final | W | 8 |
| 8 | 2021-10-30 | Lafayette | 24 | Georgetown | 23 | Final | L | -1 |
| 9 | 2021-11-06 | Fordham | 41 | Georgetown | 20 | Final | L | -21 |
| 10 | 2021-11-13 | Georgetown | 9 | Lehigh | 23 | Final | L | -14 |
| 11 | 2021-11-20 | Georgetown | 21 | Morgan State | 28 | Final | L | -7 |