Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-09-04 | Robert Morris | 0 | Dayton | 0 | Cancelled | - | - |
| 2 | 2021-09-11 | Eastern Illinois | 10 | Dayton | 17 | Final | W | 7 |
| 3 | 2021-09-18 | Dayton | 3 | Southern Illinois | 55 | Final | L | -52 |
| 4 | 2021-09-25 | Presbyterian | 43 | Dayton | 63 | Final | W | 20 |
| 5 | 2021-10-02 | Dayton | 38 | Morehead State | 45 | Final(OT) | L | -7 |
| 6 | 2021-10-09 | Dayton | 28 | Drake | 10 | Final | W | 18 |
| 7 | 2021-10-16 | Marist | 20 | Dayton | 17 | Final | L | -3 |
| 8 | 2021-10-23 | Dayton | 28 | Valparaiso | 45 | Final | L | -17 |
| 9 | 2021-10-30 | Butler | 31 | Dayton | 38 | Final | W | 7 |
| 10 | 2021-11-06 | Dayton | 41 | Stetson | 13 | Final | W | 28 |
| 11 | 2021-11-13 | Davidson | 29 | Dayton | 38 | Final | W | 9 |