Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-09-04 | Bryant | 21 | Rhode Island | 45 | Final | L | -24 |
| 2 | 2021-09-11 | Sacred Heart | 6 | Bryant | 17 | Final | W | 11 |
| 3 | 2021-09-18 | Bryant | 14 | Akron | 35 | Final | L | -21 |
| 4 | 2021-09-25 | Bryant | 34 | Marist | 17 | Final | W | 17 |
| 5 | 2021-10-02 | Brown | 29 | Bryant | 36 | Final | W | 7 |
| 6 | 2021-10-09 | Bryant | 34 | Duquesne | 39 | Final | L | -5 |
| 7 | 2021-10-23 | Bryant | 31 | Wagner | 10 | Final | W | 21 |
| 8 | 2021-11-06 | Bryant | 15 | Central Connecticut State | 30 | Final | L | -15 |
| 9 | 2021-11-13 | Long Island | 7 | Bryant | 52 | Final | W | 45 |
| 10 | 2021-11-20 | Bryant | 58 | Merrimack | 14 | Final | W | 44 |