Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-09-18 | Marist | 14 | Columbia | 37 | Final | W | 23 |
| 2 | 2021-09-25 | Georgetown | 24 | Columbia | 35 | Final | W | 11 |
| 3 | 2021-10-02 | Columbia | 7 | Princeton | 24 | Final | L | -17 |
| 4 | 2021-10-09 | Columbia | 22 | Central Connecticut State | 20 | Final | W | 2 |
| 5 | 2021-10-16 | Penn | 14 | Columbia | 23 | Final | W | 9 |
| 6 | 2021-10-22 | Columbia | 19 | Dartmouth | 0 | Final | W | 19 |
| 7 | 2021-10-30 | Columbia | 30 | Yale | 37 | Final | L | -7 |
| 8 | 2021-11-06 | Harvard | 49 | Columbia | 21 | Final | L | -28 |
| 9 | 2021-11-13 | Brown | 17 | Columbia | 23 | Final | W | 6 |
| 10 | 2021-11-20 | Columbia | 34 | Cornell | 26 | Final | W | 8 |