Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-09-04 | St. Andrews | 43 | Presbyterian | 84 | Final | W | 41 |
| 2 | 2021-09-11 | Fort Lauderdale | 3 | Presbyterian | 68 | Final | W | 65 |
| 3 | 2021-09-18 | Presbyterian | 0 | Campbell | 72 | Final | L | -72 |
| 4 | 2021-09-25 | Presbyterian | 43 | Dayton | 63 | Final | L | -20 |
| 5 | 2021-10-09 | Morehead State | 38 | Presbyterian | 30 | Final | L | -8 |
| 6 | 2021-10-16 | Presbyterian | 35 | Davidson | 70 | Final | L | -35 |
| 7 | 2021-10-23 | San Diego | 69 | Presbyterian | 28 | Final | L | -41 |
| 8 | 2021-10-30 | Stetson | 62 | Presbyterian | 14 | Final | L | -48 |
| 9 | 2021-11-06 | Presbyterian | 55 | Valparaiso | 65 | Final | L | -10 |
| 10 | 2021-11-13 | Marist | 57 | Presbyterian | 32 | Final | L | -25 |
| 11 | 2021-11-20 | Presbyterian | 15 | St. Thomas | 54 | Final | L | -39 |