Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-09-04 | Valparaiso | 10 | Indiana Wesleyan | 28 | Final | L | -18 |
| 2 | 2021-09-11 | Valparaiso | 0 | North Dakota State | 64 | Final | L | -64 |
| 3 | 2021-09-18 | Dartmouth | 28 | Valparaiso | 18 | Final | L | -10 |
| 4 | 2021-09-25 | Valparaiso | 24 | Drake | 21 | Final | W | 3 |
| 5 | 2021-10-02 | Marist | 27 | Valparaiso | 24 | Final(OT) | L | -3 |
| 6 | 2021-10-09 | Valparaiso | 13 | St. Thomas | 20 | Final | L | -7 |
| 7 | 2021-10-23 | Dayton | 28 | Valparaiso | 45 | Final | W | 17 |
| 8 | 2021-10-30 | Valparaiso | 14 | San Diego | 21 | Final | L | -7 |
| 9 | 2021-11-06 | Presbyterian | 55 | Valparaiso | 65 | Final | W | 10 |
| 10 | 2021-11-13 | Valparaiso | 47 | Butler | 3 | Final | W | 44 |
| 11 | 2021-11-20 | Morehead State | 51 | Valparaiso | 38 | Final | L | -13 |