Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-09-04 | St Francis (IL) | 0 | St. Thomas | 0 | Cancelled | - | - |
| 2 | 2021-09-11 | St. Thomas | 12 | Michigan Tech | 9 | Final | W | 3 |
| 3 | 2021-09-18 | St. Thomas | 3 | Northern Iowa | 44 | Final | L | -41 |
| 4 | 2021-09-25 | Butler | 0 | St. Thomas | 36 | Final | W | 36 |
| 5 | 2021-10-02 | St. Thomas | 24 | San Diego | 27 | Final | L | -3 |
| 6 | 2021-10-09 | Valparaiso | 13 | St. Thomas | 20 | Final | W | 7 |
| 7 | 2021-10-16 | St. Thomas | 38 | Stetson | 7 | Final | W | 31 |
| 8 | 2021-10-30 | Marist | 7 | St. Thomas | 27 | Final | W | 20 |
| 9 | 2021-11-06 | St. Thomas | 15 | Davidson | 42 | Final | L | -27 |
| 10 | 2021-11-13 | St. Thomas | 21 | Drake | 14 | Final | W | 7 |
| 11 | 2021-11-20 | Presbyterian | 15 | St. Thomas | 54 | Final | W | 39 |