Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2016-09-01 | Charlotte (125) | 14 | Louisville (39) | 70 | Final | W | 56 |
| 2 | 2016-09-09 | Louisville (39) | 62 | Syracuse (69) | 28 | Final | W | 34 |
| 3 | 2016-09-17 | Florida State (12) | 20 | Louisville (39) | 63 | Final | W | 43 |
| 4 | 2016-09-24 | Louisville (2) | 59 | Marshall (86) | 28 | Final | W | 31 |
| 5 | 2016-10-01 | Louisville (2) | 36 | Clemson (5) | 42 | Final | L | -6 |
| 6 | 2016-10-14 | Duke (83) | 14 | Louisville (8) | 24 | Final | W | 10 |
| 7 | 2016-10-22 | North Carolina State | 13 | Louisville | 54 | Final | W | 41 |
| 8 | 2016-10-29 | Louisville (7) | 32 | Virginia (110) | 25 | Final | W | 7 |
| 9 | 2016-11-05 | Louisville (7) | 52 | Boston College (78) | 7 | Final | W | 45 |
| 10 | 2016-11-12 | Wake Forest (60) | 12 | Louisville (6) | 44 | Final | W | 32 |
| 11 | 2016-11-17 | Louisville (5) | 10 | Houston (24) | 36 | Final | L | -26 |
| 12 | 2016-11-26 | Kentucky (55) | 41 | Louisville (9) | 38 | Final | L | -3 |
| 13 | 2016-12-31 | LSU (16) | 29 | Louisville (12) | 9 | Final | L | -20 |