Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2016-09-05 | Ole Miss (4) | 34 | Florida State (12) | 45 | Final | W | 11 |
| 2 | 2016-09-10 | Charleston Southern | 8 | Florida State | 52 | Final | W | 44 |
| 3 | 2016-09-17 | Florida State (12) | 20 | Louisville (39) | 63 | Final | L | -43 |
| 4 | 2016-09-24 | Florida State | 55 | South Florida | 35 | Final | W | 20 |
| 5 | 2016-10-01 | North Carolina (42) | 37 | Florida State (27) | 35 | Final | L | -2 |
| 6 | 2016-10-08 | Florida State (34) | 20 | Miami (7) | 19 | Final | W | 1 |
| 7 | 2016-10-15 | Wake Forest (22) | 6 | Florida State (21) | 17 | Final | W | 11 |
| 8 | 2016-10-29 | Clemson (3) | 37 | Florida State (20) | 34 | Final | L | -3 |
| 9 | 2016-11-05 | Florida State | 24 | North Carolina State | 20 | Final | W | 4 |
| 10 | 2016-11-11 | Boston College (84) | 7 | Florida State (21) | 45 | Final | W | 38 |
| 11 | 2016-11-19 | Florida State (21) | 45 | Syracuse (84) | 14 | Final | W | 31 |
| 12 | 2016-11-26 | Florida (17) | 13 | Florida State (20) | 31 | Final | W | 18 |
| 13 | 2016-12-30 | Michigan (3) | 32 | Florida State (13) | 33 | Final | W | 1 |