Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2016-09-03 | Oklahoma (9) | 23 | Houston (8) | 33 | Final | W | 10 |
| 2 | 2016-09-10 | Lamar | 0 | Houston | 42 | Final | W | 42 |
| 3 | 2016-09-15 | Houston (8) | 40 | Cincinnati (64) | 16 | Final | W | 24 |
| 4 | 2016-09-24 | Houston (11) | 64 | Texas State (60) | 3 | Final | W | 61 |
| 5 | 2016-09-29 | Connecticut | 14 | Houston | 42 | Final | W | 28 |
| 6 | 2016-10-08 | Houston (8) | 40 | Navy (43) | 46 | Final | L | -6 |
| 7 | 2016-10-15 | Tulsa (47) | 31 | Houston (13) | 38 | Final | W | 7 |
| 8 | 2016-10-22 | Houston (13) | 16 | SMU (103) | 38 | Final | L | -22 |
| 9 | 2016-10-29 | Central Florida | 24 | Houston | 31 | Final | W | 7 |
| 10 | 2016-11-12 | Tulane (101) | 18 | Houston (26) | 30 | Final | W | 12 |
| 11 | 2016-11-17 | Louisville (5) | 10 | Houston (24) | 36 | Final | W | 26 |
| 12 | 2016-11-25 | Houston (16) | 44 | Memphis (44) | 48 | Final | L | -4 |
| 13 | 2016-12-17 | Houston (21) | 10 | San Diego State (43) | 34 | Final | L | -24 |