Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2016-09-03 | South Carolina State | 0 | Central Florida | 38 | Final | L | -38 |
| 2 | 2016-09-10 | South Carolina State | 24 | Louisiana Tech | 53 | Final | L | -29 |
| 3 | 2016-09-17 | South Carolina State | 0 | Clemson | 59 | Final | L | -59 |
| 4 | 2016-09-24 | South Carolina State | 48 | Florida A&M | 14 | Final | W | 34 |
| 5 | 2016-10-08 | Bethune-Cookman | 0 | South Carolina State | 0 | Postponed | - | - |
| 6 | 2016-10-15 | South Carolina State | 14 | Howard | 9 | Final | W | 5 |
| 7 | 2016-10-22 | Delaware State | 3 | South Carolina State | 30 | Final | W | 27 |
| 8 | 2016-10-29 | South Carolina State | 26 | Hampton | 28 | Final | L | -2 |
| 9 | 2016-11-05 | South Carolina State | 20 | North Carolina A&T | 30 | Final | L | -10 |
| 10 | 2016-11-12 | Norfolk State | 13 | South Carolina State | 10 | Final | L | -3 |
| 11 | 2016-11-19 | Savannah State | 0 | South Carolina State | 32 | Final | W | 32 |
| 12 | 2016-11-26 | Bethune-Cookman | 7 | South Carolina State | 28 | Final | W | 21 |