Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2016-09-03 | Bowling Green (28) | 10 | Ohio State (3) | 77 | Final | W | 67 |
| 2 | 2016-09-10 | Tulsa (94) | 3 | Ohio State (3) | 48 | Final | W | 45 |
| 3 | 2016-09-17 | Ohio State (3) | 45 | Oklahoma (9) | 24 | Final | W | 21 |
| 4 | 2016-10-01 | Rutgers (88) | 0 | Ohio State (6) | 58 | Final | W | 58 |
| 5 | 2016-10-08 | Indiana (39) | 17 | Ohio State (5) | 38 | Final | W | 21 |
| 6 | 2016-10-15 | Ohio State (4) | 30 | Wisconsin (12) | 23 | Final/OT | W | 7 |
| 7 | 2016-10-22 | Ohio State (4) | 21 | Penn State (28) | 24 | Final | L | -3 |
| 8 | 2016-10-29 | Northwestern (53) | 20 | Ohio State (8) | 24 | Final | W | 4 |
| 9 | 2016-11-05 | Nebraska (11) | 3 | Ohio State (5) | 62 | Final | W | 59 |
| 10 | 2016-11-12 | Ohio State (4) | 62 | Maryland (53) | 3 | Final | W | 59 |
| 11 | 2016-11-19 | Ohio State (2) | 17 | Michigan State (91) | 16 | Final | W | 1 |
| 12 | 2016-11-26 | Michigan (3) | 27 | Ohio State (2) | 30 | Final/2OT | W | 3 |
| 13 | 2016-12-31 | Ohio State (2) | 0 | Clemson (5) | 31 | Final | L | -31 |