Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2020-11-25 | North Carolina Central (341) | 67 | 97 | Iowa (28) | Final | W | 30 |
| 2 | 2020-11-27 | Southern (259) | 76 | 103 | Iowa (28) | Final | W | 27 |
| 3 | 2020-12-03 | Western Illinois (362) | 58 | 99 | Iowa (28) | Final | W | 41 |
| 4 | 2020-12-08 | North Carolina (22) | 80 | 93 | Iowa (28) | Final | W | 13 |
| 5 | 2020-12-11 | Iowa State (7) | 77 | 105 | Iowa (28) | Final | W | 28 |
| 6 | 2020-12-13 | Northern Illinois (326) | 53 | 106 | Iowa (28) | Final | W | 53 |
| 7 | 2020-12-19 | Iowa (28) | 88 | 99 | Gonzaga (11) | Final | L | -11 |
| 8 | 2020-12-19 | Gonzaga (1) | 99 | 88 | Iowa (8) | Final | L | -11 |
| 9 | 2020-12-22 | Purdue (8) | 55 | 70 | Iowa (28) | Final | W | 15 |
| 10 | 2020-12-25 | Iowa (13) | 95 | 102 | Minnesota (23) | Final (OT) | L | -7 |
| 11 | 2020-12-29 | Northwestern (75) | 72 | 87 | Iowa (28) | Final | W | 15 |
| 12 | 2021-01-02 | Iowa (28) | 77 | 75 | Rutgers (112) | Final | W | 2 |
| 13 | 2021-01-07 | Iowa (28) | 89 | 67 | Maryland (114) | Final | W | 22 |
| 14 | 2021-01-10 | Minnesota (87) | 71 | 86 | Iowa (28) | Final | W | 15 |
| 15 | 2021-01-14 | Michigan State (10) | 0 | 0 | Iowa (28) | Postponed | - | - |
| 16 | 2021-01-17 | Iowa (28) | 96 | 73 | Northwestern (75) | Final | W | 23 |
| 17 | 2021-01-21 | Indiana (46) | 81 | 69 | Iowa (28) | Final | L | -12 |
| 18 | 2021-01-24 | Nebraska (13) | 0 | 0 | Iowa (28) | Postponed | - | - |
| 19 | 2021-01-29 | Iowa (28) | 75 | 80 | Illinois (9) | Final | L | -5 |
| 20 | 2021-02-02 | Michigan State (10) | 78 | 84 | Iowa (28) | Final | W | 6 |
| 21 | 2021-02-04 | Ohio State (34) | 89 | 85 | Iowa (28) | Final | L | -4 |
| 22 | 2021-02-07 | Iowa (28) | 65 | 67 | Indiana (46) | Final | L | -2 |
| 23 | 2021-02-10 | Rutgers (112) | 66 | 79 | Iowa (28) | Final | W | 13 |
| 24 | 2021-02-13 | Iowa (28) | 88 | 58 | Michigan State (10) | Final | W | 30 |
| 25 | 2021-02-18 | Iowa (28) | 77 | 62 | Wisconsin (24) | Final | W | 15 |
| 26 | 2021-02-21 | Penn State (129) | 68 | 74 | Iowa (28) | Final | W | 6 |
| 27 | 2021-02-25 | Iowa (28) | 57 | 79 | Michigan (1) | Final | L | -22 |
| 28 | 2021-02-28 | Iowa (28) | 73 | 57 | Ohio State (34) | Final | W | 16 |
| 29 | 2021-03-04 | Nebraska (13) | 64 | 102 | Iowa (28) | Final | W | 38 |
| 30 | 2021-03-07 | Wisconsin (24) | 73 | 77 | Iowa (28) | Final | W | 4 |
| 31 | 2021-03-12 | Wisconsin (24) | 57 | 62 | Iowa (28) | Final | W | 5 |
| 32 | 2021-03-13 | Iowa (6) | 71 | 82 | Illinois (4) | Final | L | -11 |
| 33 | 2021-03-20 | Grand Canyon (108) | 74 | 86 | Iowa (7) | Final | W | 12 |
| 34 | 2021-03-22 | Oregon (28) | 95 | 80 | Iowa (7) | Final | L | -15 |