Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2020-11-25 | Drexel (215) | 0 | 0 | Penn State (129) | Cancelled | - | - |
| 2 | 2020-11-28 | Virginia Military (357) | 65 | 86 | Penn State (129) | Final | W | 21 |
| 3 | 2020-12-02 | Virginia Commonwealth (38) | 69 | 72 | Penn State (129) | Final | W | 3 |
| 4 | 2020-12-06 | Seton Hall (53) | 98 | 92 | Penn State (129) | Final/OT | L | -6 |
| 5 | 2020-12-08 | Penn State (129) | 75 | 55 | Virginia Tech (56) | Final | W | 20 |
| 6 | 2020-12-13 | Penn State (129) | 58 | 62 | Michigan (1) | Final | L | -4 |
| 7 | 2020-12-23 | Illinois (9) | 98 | 81 | Penn State (129) | Final | L | -17 |
| 8 | 2020-12-30 | Penn State (129) | 85 | 87 | Indiana (46) | Final/OT | L | -2 |
| 9 | 2021-01-03 | Wisconsin (24) | 0 | 0 | Penn State (129) | Postponed | - | - |
| 10 | 2021-01-06 | Penn State (129) | 0 | 0 | Ohio State (34) | Postponed | - | - |
| 11 | 2021-01-09 | Michigan (1) | 0 | 0 | Penn State (129) | Cancelled | - | - |
| 12 | 2021-01-12 | Rutgers (112) | 0 | 0 | Penn State (129) | Postponed | - | - |
| 13 | 2021-01-17 | Penn State (129) | 72 | 80 | Purdue (8) | Final | L | -8 |
| 14 | 2021-01-19 | Penn State (129) | 65 | 79 | Illinois (9) | Final | L | -14 |
| 15 | 2021-01-21 | Rutgers (112) | 67 | 75 | Penn State (129) | Final | W | 8 |
| 16 | 2021-01-23 | Northwestern (75) | 78 | 81 | Penn State (129) | Final | W | 3 |
| 17 | 2021-01-27 | Michigan (3) | 0 | 0 | Penn State (57) | Cancelled | - | - |
| 18 | 2021-01-27 | Penn State (129) | 79 | 83 | Ohio State (34) | Final | L | -4 |
| 19 | 2021-01-30 | Penn State (57) | 0 | 0 | Nebraska (161) | Cancelled | - | - |
| 20 | 2021-01-30 | Wisconsin (24) | 71 | 81 | Penn State (129) | Final | W | 10 |
| 21 | 2021-02-02 | Penn State (129) | 56 | 72 | Wisconsin (24) | Final | L | -16 |
| 22 | 2021-02-05 | Maryland (114) | 50 | 55 | Penn State (129) | Final | W | 5 |
| 23 | 2021-02-09 | Penn State (129) | 58 | 60 | Michigan State (10) | Final | L | -2 |
| 24 | 2021-02-14 | Nebraska (13) | 62 | 61 | Penn State (129) | Final | L | -1 |
| 25 | 2021-02-18 | Ohio State (34) | 92 | 82 | Penn State (129) | Final | L | -10 |
| 26 | 2021-02-21 | Penn State (129) | 68 | 74 | Iowa (28) | Final | L | -6 |
| 27 | 2021-02-23 | Penn State (129) | 86 | 83 | Nebraska (13) | Final | W | 3 |
| 28 | 2021-02-26 | Purdue (8) | 73 | 52 | Penn State (129) | Final | L | -21 |
| 29 | 2021-03-03 | Minnesota (87) | 65 | 84 | Penn State (129) | Final | W | 19 |
| 30 | 2021-03-07 | Penn State (129) | 66 | 61 | Maryland (114) | Final | W | 5 |
| 31 | 2021-03-10 | Nebraska (140) | 66 | 72 | Penn State (59) | Final | W | 6 |
| 32 | 2021-03-11 | Penn State (129) | 74 | 75 | Wisconsin (24) | Final | L | -1 |