Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2020-11-25 | Western Michigan (304) | 62 | 66 | Butler (80) | Final | W | 4 |
| 2 | 2020-11-29 | Eastern Illinois (314) | 0 | 0 | Butler (80) | Cancelled | - | - |
| 3 | 2020-12-06 | Northern Kentucky (195) | 0 | 0 | Butler (80) | Cancelled | - | - |
| 4 | 2020-12-11 | Kansas State (297) | 0 | 0 | Butler (107) | Cancelled | - | - |
| 5 | 2020-12-14 | St. John's (12) | 0 | 0 | Butler (80) | Postponed | - | - |
| 6 | 2020-12-16 | Butler (80) | 66 | 85 | Villanova (29) | Final | L | -19 |
| 7 | 2020-12-19 | Butler (80) | 60 | 68 | Indiana (46) | Final | L | -8 |
| 8 | 2020-12-19 | Indiana (43) | 68 | 60 | Butler (152) | Final | L | -8 |
| 9 | 2020-12-21 | DePaul (180) | 0 | 0 | Butler (152) | Cancelled | - | - |
| 10 | 2020-12-21 | Southern Illinois (150) | 76 | 73 | Butler (80) | Final | L | -3 |
| 11 | 2020-12-23 | Providence (82) | 64 | 70 | Butler (80) | Final | W | 6 |
| 12 | 2020-12-30 | Butler (80) | 55 | 71 | Providence (82) | Final | L | -16 |
| 13 | 2021-01-02 | Butler (80) | 60 | 68 | Seton Hall (53) | Final | L | -8 |
| 14 | 2021-01-06 | Georgetown (83) | 55 | 63 | Butler (80) | Final | W | 8 |
| 15 | 2021-01-09 | Connecticut (4) | 72 | 60 | Butler (80) | Final | L | -12 |
| 16 | 2021-01-12 | Butler (80) | 57 | 69 | St. John's (12) | Final | L | -12 |
| 17 | 2021-01-16 | Creighton (78) | 66 | 70 | Butler (80) | Final/OT | W | 4 |
| 18 | 2021-01-19 | Butler (80) | 67 | 53 | DePaul (95) | Final | W | 14 |
| 19 | 2021-01-22 | Seton Hall (53) | 0 | 0 | Butler (80) | Postponed | - | - |
| 20 | 2021-01-26 | Butler (80) | 51 | 63 | Connecticut (4) | Final | L | -12 |
| 21 | 2021-01-29 | Xavier (92) | 0 | 0 | Butler (80) | Postponed | - | - |
| 22 | 2021-01-30 | Xavier (92) | 68 | 55 | Butler (80) | Final | L | -13 |
| 23 | 2021-02-02 | Butler (80) | 67 | 70 | Marquette (106) | Final | L | -3 |
| 24 | 2021-02-06 | DePaul (95) | 58 | 68 | Butler (80) | Final | W | 10 |
| 25 | 2021-02-09 | St. John's (12) | 73 | 76 | Butler (80) | Final/OT | W | 3 |
| 26 | 2021-02-13 | Butler (80) | 63 | 78 | Georgetown (83) | Final | L | -15 |
| 27 | 2021-02-17 | Marquette (106) | 73 | 57 | Butler (80) | Final | L | -16 |
| 28 | 2021-02-21 | Butler (80) | 51 | 63 | Xavier (92) | Final | L | -12 |
| 29 | 2021-02-24 | Seton Hall (53) | 52 | 61 | Butler (80) | Final | W | 9 |
| 30 | 2021-02-28 | Villanova (29) | 61 | 73 | Butler (80) | Final | W | 12 |
| 31 | 2021-03-06 | Butler (80) | 73 | 93 | Creighton (78) | Final | L | -20 |
| 32 | 2021-03-10 | Butler (120) | 70 | 69 | Xavier (55) | Final (OT) | W | 1 |
| 33 | 2021-03-11 | Butler (80) | 56 | 87 | Creighton (78) | Final | L | -31 |