Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2020-11-25 | Saint Peter's (200) | 75 | 76 | St. John's (12) | Final | W | 1 |
| 2 | 2020-11-26 | La Salle (237) | 65 | 82 | St. John's (12) | Final | W | 17 |
| 3 | 2020-11-30 | St. John's (12) | 97 | 93 | Boston College (151) | Final | W | 4 |
| 4 | 2020-11-30 | Boston College (133) | 93 | 97 | St. John's (62) | Final | W | 4 |
| 5 | 2020-12-02 | St. John's (12) | 68 | 74 | BYU (23) | Final | L | -6 |
| 6 | 2020-12-03 | St. John's (12) | 0 | 0 | Texas Tech (20) | Cancelled | - | - |
| 7 | 2020-12-03 | St. John's (37) | Texas Tech (71) | Cancelled | - | - | ||
| 8 | 2020-12-06 | Sacred Heart (279) | St. John's (37) | Cancelled | - | - | ||
| 9 | 2020-12-06 | Stony Brook (213) | 66 | 89 | St. John's (12) | Final | W | 23 |
| 10 | 2020-12-08 | Fordham (171) | St. John's (52) | Cancelled | - | - | ||
| 11 | 2020-12-08 | Rider (356) | 79 | 82 | St. John's (12) | Final | W | 3 |
| 12 | 2020-12-11 | St. John's (52) | 0 | 0 | Connecticut (23) | Cancelled | - | - |
| 13 | 2020-12-11 | St. John's (12) | 68 | 77 | Seton Hall (53) | Final | L | -9 |
| 14 | 2020-12-13 | St. John's (12) | 94 | 97 | Georgetown (83) | Final/OT | L | -3 |
| 15 | 2020-12-14 | St. John's (12) | 0 | 0 | Butler (80) | Postponed | - | - |
| 16 | 2020-12-17 | Creighton (78) | 94 | 76 | St. John's (12) | Final | L | -18 |
| 17 | 2020-12-20 | Georgetown (83) | 83 | 94 | St. John's (12) | Final | W | 11 |
| 18 | 2020-12-30 | St. John's (12) | 0 | 0 | Villanova (29) | Postponed | - | - |
| 19 | 2021-01-02 | DePaul (95) | 0 | 0 | St. John's (12) | Postponed | - | - |
| 20 | 2021-01-06 | St. John's (12) | 61 | 69 | Xavier (92) | Final | L | -8 |
| 21 | 2021-01-09 | St. John's (12) | 79 | 97 | Creighton (78) | Final | L | -18 |
| 22 | 2021-01-12 | Butler (80) | 57 | 69 | St. John's (12) | Final | W | 12 |
| 23 | 2021-01-16 | Marquette (106) | 73 | 71 | St. John's (12) | Final | L | -2 |
| 24 | 2021-01-18 | St. John's (12) | 74 | 70 | Connecticut (4) | Final | W | 4 |
| 25 | 2021-01-23 | Utah Valley (91) | 78 | 96 | St. John's (12) | Final | W | 18 |
| 26 | 2021-01-27 | St. John's (12) | 81 | 68 | DePaul (95) | Final | W | 13 |
| 27 | 2021-01-31 | Connecticut (45) | 0 | 0 | St. John's (78) | Cancelled | - | - |
| 28 | 2021-01-31 | St. John's (12) | 75 | 73 | Marquette (106) | Final | W | 2 |
| 29 | 2021-02-03 | Villanova (29) | 59 | 70 | St. John's (12) | Final | W | 11 |
| 30 | 2021-02-06 | St. John's (12) | 92 | 81 | Providence (82) | Final | W | 11 |
| 31 | 2021-02-09 | St. John's (12) | 73 | 76 | Butler (80) | Final/OT | L | -3 |
| 32 | 2021-02-16 | Xavier (92) | 84 | 93 | St. John's (12) | Final | W | 9 |
| 33 | 2021-02-20 | DePaul (95) | 88 | 83 | St. John's (12) | Final | L | -5 |
| 34 | 2021-02-23 | St. John's (12) | 58 | 81 | Villanova (29) | Final | L | -23 |
| 35 | 2021-03-03 | Providence (82) | 67 | 81 | St. John's (12) | Final | W | 14 |
| 36 | 2021-03-06 | Seton Hall (53) | 71 | 81 | St. John's (12) | Final | W | 10 |
| 37 | 2021-03-11 | Seton Hall (53) | 77 | 69 | St. John's (12) | Final/OT | L | -8 |