Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2020-11-25 | Oakland (172) | 49 | 101 | Xavier (92) | Final | W | 52 |
| 2 | 2020-11-26 | Bradley (113) | 50 | 51 | Xavier (92) | Final | W | 1 |
| 3 | 2020-11-27 | Toledo (135) | 73 | 76 | Xavier (92) | Final | W | 3 |
| 4 | 2020-11-30 | Eastern Kentucky (288) | 96 | 99 | Xavier (92) | Final/OT | W | 3 |
| 5 | 2020-12-02 | Tennessee Tech (310) | 48 | 79 | Xavier (92) | Final | W | 31 |
| 6 | 2020-12-06 | Xavier (92) | 77 | 69 | Cincinnati (54) | Final | W | 8 |
| 7 | 2020-12-09 | Oklahoma (47) | 77 | 99 | Xavier (92) | Final | W | 22 |
| 8 | 2020-12-12 | Xavier (92) | 0 | 0 | Providence (82) | Postponed | - | - |
| 9 | 2020-12-15 | Seton Hall (53) | 0 | 0 | Xavier (92) | Postponed | - | - |
| 10 | 2020-12-18 | Xavier (92) | 0 | 0 | DePaul (95) | Cancelled | - | - |
| 11 | 2020-12-20 | Marquette (106) | 88 | 91 | Xavier (92) | Final | W | 3 |
| 12 | 2020-12-23 | Xavier (92) | 61 | 66 | Creighton (78) | Final | L | -5 |
| 13 | 2020-12-30 | Seton Hall (53) | 85 | 68 | Xavier (92) | Final | L | -17 |
| 14 | 2021-01-02 | Villanova (29) | 0 | 0 | Xavier (92) | Cancelled | - | - |
| 15 | 2021-01-06 | St. John's (12) | 61 | 69 | Xavier (92) | Final | W | 8 |
| 16 | 2021-01-10 | Providence (82) | 73 | 74 | Xavier (92) | Final | W | 1 |
| 17 | 2021-01-13 | Villanova (29) | 0 | 0 | Xavier (92) | Cancelled | - | - |
| 18 | 2021-01-16 | Xavier (92) | 0 | 0 | Seton Hall (53) | Cancelled | - | - |
| 19 | 2021-01-20 | Xavier (92) | 0 | 0 | Connecticut (4) | Cancelled | - | - |
| 20 | 2021-01-26 | Georgetown (83) | 0 | 0 | Xavier (92) | Cancelled | - | - |
| 21 | 2021-01-29 | Xavier (92) | 0 | 0 | Butler (80) | Postponed | - | - |
| 22 | 2021-01-30 | Xavier (92) | 68 | 55 | Butler (80) | Final | W | 13 |
| 23 | 2021-02-03 | Xavier (92) | 0 | 0 | DePaul (95) | Cancelled | - | - |
| 24 | 2021-02-07 | Xavier (19) | 0 | 0 | Villanova (10) | Cancelled | - | - |
| 25 | 2021-02-11 | DePaul (95) | 0 | 0 | Xavier (92) | Postponed | - | - |
| 26 | 2021-02-13 | Connecticut (4) | 80 | 72 | Xavier (92) | Final | L | -8 |
| 27 | 2021-02-16 | Xavier (92) | 84 | 93 | St. John's (12) | Final | L | -9 |
| 28 | 2021-02-21 | Butler (80) | 51 | 63 | Xavier (92) | Final | W | 12 |
| 29 | 2021-02-24 | Xavier (92) | 68 | 83 | Providence (82) | Final | L | -15 |
| 30 | 2021-02-27 | Creighton (78) | 69 | 77 | Xavier (92) | Final | W | 8 |
| 31 | 2021-03-02 | Xavier (92) | 66 | 72 | Georgetown (83) | Final | L | -6 |
| 32 | 2021-03-06 | Xavier (92) | 59 | 66 | Marquette (106) | Final | L | -7 |
| 33 | 2021-03-10 | Butler (120) | 70 | 69 | Xavier (55) | Final (OT) | L | -1 |