Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2020-12-02 | Southern Illinois (150) | 87 | 79 | Southeast Missouri State (226) | Final/OT | W | 8 |
| 2 | 2020-12-05 | Southern Miss (201) | 0 | 0 | Southern Illinois (150) | Cancelled | - | - |
| 3 | 2020-12-05 | Southern Miss (291) | Southern Illinois (213) | Cancelled | - | - | ||
| 4 | 2020-12-06 | Quincy | 61 | 102 | Southern Illinois (150) | Final | W | 41 |
| 5 | 2020-12-11 | Murray State (116) | 66 | 70 | Southern Illinois (150) | Final | W | 4 |
| 6 | 2020-12-17 | North Dakota (251) | 64 | 85 | Southern Illinois (150) | Final | W | 21 |
| 7 | 2020-12-18 | North Dakota (251) | 50 | 62 | Southern Illinois (150) | Final | W | 12 |
| 8 | 2020-12-21 | Southern Illinois (150) | 76 | 73 | Butler (80) | Final | W | 3 |
| 9 | 2020-12-22 | Nicholls State (250) | 0 | 0 | Southern Illinois (150) | Cancelled | - | - |
| 10 | 2020-12-23 | Nicholls State (224) | Southern Illinois (59) | Cancelled | - | - | ||
| 11 | 2020-12-27 | Evansville (302) | 57 | 63 | Southern Illinois (150) | Final | W | 6 |
| 12 | 2020-12-28 | Evansville (302) | 84 | 72 | Southern Illinois (150) | Final | L | -12 |
| 13 | 2020-12-31 | Bradley (89) | Southern Illinois (53) | Cancelled | - | - | ||
| 14 | 2021-01-03 | Southern Illinois (53) | Illinois State (255) | Cancelled | - | - | ||
| 15 | 2021-01-03 | Southern Illinois (150) | 55 | 73 | Drake (217) | Final | L | -18 |
| 16 | 2021-01-04 | Southern Illinois (150) | 55 | 86 | Drake (217) | Final | L | -31 |
| 17 | 2021-01-06 | Southern Illinois (114) | Indiana State (220) | Cancelled | - | - | ||
| 18 | 2021-01-09 | Valparaiso (275) | Southern Illinois (114) | Cancelled | - | - | ||
| 19 | 2021-01-09 | Southern Illinois (150) | 0 | 0 | Indiana State (243) | Postponed | - | - |
| 20 | 2021-01-10 | Southern Illinois (114) | 0 | 0 | Indiana State (220) | Cancelled | - | - |
| 21 | 2021-01-13 | Southern Illinois | Missouri State | Cancelled | - | - | ||
| 22 | 2021-01-16 | Valparaiso (280) | 0 | 0 | Southern Illinois (126) | Cancelled | - | - |
| 23 | 2021-01-17 | Northern Iowa | Southern Illinois | Cancelled | - | - | ||
| 24 | 2021-01-17 | Valparaiso (156) | 0 | 0 | Southern Illinois (150) | Postponed | - | - |
| 25 | 2021-01-20 | Drake | Southern Illinois | Cancelled | - | - | ||
| 26 | 2021-01-23 | Southern Illinois | Bradley | Cancelled | - | - | ||
| 27 | 2021-01-25 | Southern Illinois (150) | 66 | 69 | Indiana State (243) | Final | L | -3 |
| 28 | 2021-01-26 | Southern Illinois (150) | 59 | 71 | Indiana State (243) | Final | L | -12 |
| 29 | 2021-01-27 | Loyola-Chicago | Southern Illinois | Cancelled | - | - | ||
| 30 | 2021-01-30 | Southern Illinois | Evansville | Cancelled | - | - | ||
| 31 | 2021-01-30 | Northern Iowa (89) | 74 | 62 | Southern Illinois (150) | Final | L | -12 |
| 32 | 2021-01-31 | Northern Iowa (89) | 68 | 71 | Southern Illinois (150) | Final | W | 3 |
| 33 | 2021-02-02 | Southern Illinois | Valparaiso | Cancelled | - | - | ||
| 34 | 2021-02-06 | Indiana State | Southern Illinois | Cancelled | - | - | ||
| 35 | 2021-02-06 | Southern Illinois (150) | 66 | 74 | Bradley (113) | Final | L | -8 |
| 36 | 2021-02-07 | Southern Illinois (150) | 69 | 68 | Bradley (113) | Final | W | 1 |
| 37 | 2021-02-09 | Southern Illinois | Loyola-Chicago | Cancelled | - | - | ||
| 38 | 2021-02-10 | Southern Illinois (150) | 53 | 65 | Missouri State (224) | Final | L | -12 |
| 39 | 2021-02-13 | Illinois State (94) | 80 | 55 | Southern Illinois (150) | Final | L | -25 |
| 40 | 2021-02-14 | Illinois State (94) | 49 | 59 | Southern Illinois (150) | Final | W | 10 |
| 41 | 2021-02-17 | Evansville | Southern Illinois | Cancelled | - | - | ||
| 42 | 2021-02-17 | Missouri State (224) | 68 | 53 | Southern Illinois (150) | Final | L | -15 |
| 43 | 2021-02-21 | Southern Illinois | Drake | Cancelled | - | - | ||
| 44 | 2021-02-21 | Valparaiso (156) | 66 | 65 | Southern Illinois (150) | Final | L | -1 |
| 45 | 2021-02-22 | Valparaiso (156) | 64 | 67 | Southern Illinois (150) | Final | W | 3 |
| 46 | 2021-02-24 | Southern Illinois | Northern Iowa | Cancelled | - | - | ||
| 47 | 2021-02-26 | Southern Illinois (150) | 52 | 60 | Loyola-Chicago (263) | Final | L | -8 |
| 48 | 2021-02-27 | Missouri State | Southern Illinois | Cancelled | - | - | ||
| 49 | 2021-02-27 | Southern Illinois (150) | 58 | 65 | Loyola-Chicago (263) | Final/OT | L | -7 |
| 50 | 2021-03-04 | Southern Illinois (150) | 73 | 63 | Bradley (113) | Final | W | 10 |
| 51 | 2021-03-05 | Southern Illinois (150) | 49 | 73 | Loyola-Chicago (263) | Final | L | -24 |