Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2020-11-29 | North Dakota State (117) | 58 | 69 | Creighton (78) | Final | W | 11 |
| 2 | 2020-12-01 | Nebraska-Omaha (272) | 67 | 94 | Creighton (78) | Final | W | 27 |
| 3 | 2020-12-04 | Kennesaw State (142) | 58 | 93 | Creighton (78) | Final | W | 35 |
| 4 | 2020-12-08 | Creighton (78) | 72 | 73 | Kansas (19) | Final | L | -1 |
| 5 | 2020-12-11 | Nebraska (13) | 74 | 98 | Creighton (78) | Final | W | 24 |
| 6 | 2020-12-14 | Marquette (106) | 89 | 84 | Creighton (78) | Final | L | -5 |
| 7 | 2020-12-17 | Creighton (78) | 94 | 76 | St. John's (12) | Final | W | 18 |
| 8 | 2020-12-20 | Creighton (78) | 76 | 74 | Connecticut (4) | Final/OT | W | 2 |
| 9 | 2020-12-23 | Xavier (92) | 61 | 66 | Creighton (78) | Final | W | 5 |
| 10 | 2021-01-02 | Creighton (78) | 67 | 65 | Providence (82) | Final | W | 2 |
| 11 | 2021-01-06 | Seton Hall (53) | 53 | 89 | Creighton (78) | Final | W | 36 |
| 12 | 2021-01-09 | St. John's (12) | 79 | 97 | Creighton (78) | Final | W | 18 |
| 13 | 2021-01-16 | Creighton (78) | 66 | 70 | Butler (80) | Final/OT | L | -4 |
| 14 | 2021-01-20 | Providence (82) | 74 | 70 | Creighton (78) | Final | L | -4 |
| 15 | 2021-01-23 | Connecticut (4) | 66 | 74 | Creighton (78) | Final | W | 8 |
| 16 | 2021-01-27 | Creighton (78) | 85 | 81 | Seton Hall (53) | Final | W | 4 |
| 17 | 2021-01-30 | Creighton (78) | 69 | 62 | DePaul (95) | Final | W | 7 |
| 18 | 2021-02-03 | Georgetown (83) | 86 | 79 | Creighton (78) | Final | L | -7 |
| 19 | 2021-02-06 | Creighton (78) | 71 | 68 | Marquette (106) | Final | W | 3 |
| 20 | 2021-02-09 | Creighton (78) | 63 | 48 | Georgetown (83) | Final | W | 15 |
| 21 | 2021-02-13 | Villanova (29) | 70 | 86 | Creighton (78) | Final | W | 16 |
| 22 | 2021-02-24 | DePaul (95) | 53 | 77 | Creighton (78) | Final | W | 24 |
| 23 | 2021-02-27 | Creighton (78) | 69 | 77 | Xavier (92) | Final | L | -8 |
| 24 | 2021-03-03 | Creighton (78) | 60 | 72 | Villanova (29) | Final | L | -12 |
| 25 | 2021-03-06 | Butler (80) | 73 | 93 | Creighton (78) | Final | W | 20 |
| 26 | 2021-03-11 | Butler (80) | 56 | 87 | Creighton (78) | Final | W | 31 |
| 27 | 2021-03-12 | Connecticut (4) | 56 | 59 | Creighton (78) | Final | W | 3 |
| 28 | 2021-03-13 | Georgetown (93) | 73 | 48 | Creighton (27) | Final | L | -25 |
| 29 | 2021-03-20 | UC-Santa Barbara (56) | 62 | 63 | Creighton (25) | Final | W | 1 |
| 30 | 2021-03-22 | Ohio (95) | 58 | 72 | Creighton (25) | Final | W | 14 |
| 31 | 2021-03-28 | Creighton (25) | 65 | 83 | Gonzaga (1) | Final | L | -18 |