Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2020-11-25 | Eastern Illinois (314) | 67 | 77 | Wisconsin (24) | Final | L | -10 |
| 2 | 2020-11-27 | Eastern Illinois (314) | 50 | 75 | Marquette (106) | Final | L | -25 |
| 3 | 2020-11-29 | Eastern Illinois (314) | 0 | 0 | Butler (80) | Cancelled | - | - |
| 4 | 2020-12-01 | Eastern Illinois (314) | 63 | 66 | Dayton (66) | Final | L | -3 |
| 5 | 2020-12-03 | Chicago State (351) | 56 | 78 | Eastern Illinois (314) | Final | W | 22 |
| 6 | 2020-12-05 | Eastern Illinois (314) | 93 | 91 | Green Bay (206) | Final/2OT | W | 2 |
| 7 | 2020-12-09 | Eastern Illinois (314) | 65 | 68 | Evansville (302) | Final | L | -3 |
| 8 | 2020-12-12 | Western Illinois (362) | 88 | 92 | Eastern Illinois (314) | Final | W | 4 |
| 9 | 2020-12-21 | Eastern Illinois (314) | 0 | 0 | SIU-Edwardsville (248) | Postponed | - | - |
| 10 | 2020-12-30 | Eastern Illinois (314) | 61 | 69 | Eastern Kentucky (288) | Final | L | -8 |
| 11 | 2021-01-02 | Tennessee Tech (310) | 81 | 87 | Eastern Illinois (314) | Final | W | 6 |
| 12 | 2021-01-05 | SIU-Edwardsville (248) | 0 | 0 | Eastern Illinois (314) | Postponed | - | - |
| 13 | 2021-01-07 | Murray State (116) | 68 | 74 | Eastern Illinois (314) | Final | W | 6 |
| 14 | 2021-01-09 | Austin Peay (138) | 74 | 71 | Eastern Illinois (314) | Final | L | -3 |
| 15 | 2021-01-12 | Eastern Illinois (314) | 0 | 0 | SIU-Edwardsville (248) | Postponed | - | - |
| 16 | 2021-01-14 | Morehead State (233) | 87 | 61 | Eastern Illinois (314) | Final | L | -26 |
| 17 | 2021-01-16 | Eastern Kentucky (288) | 93 | 85 | Eastern Illinois (314) | Final/OT | L | -8 |
| 18 | 2021-01-21 | Eastern Illinois (314) | 66 | 79 | Belmont (68) | Final | L | -13 |
| 19 | 2021-01-23 | Eastern Illinois (314) | 54 | 65 | Tennessee State (165) | Final | L | -11 |
| 20 | 2021-01-26 | SIU-Edwardsville (248) | 87 | 74 | Eastern Illinois (314) | Final | L | -13 |
| 21 | 2021-01-28 | Eastern Illinois (314) | 41 | 51 | Tennessee-Martin (205) | Final | L | -10 |
| 22 | 2021-01-30 | Eastern Illinois (314) | 44 | 75 | Southeast Missouri State (226) | Final | L | -31 |
| 23 | 2021-02-02 | Eastern Illinois (314) | 70 | 61 | SIU-Edwardsville (248) | Final | W | 9 |
| 24 | 2021-02-04 | Belmont (68) | 89 | 61 | Eastern Illinois (314) | Final | L | -28 |
| 25 | 2021-02-06 | Tennessee State (165) | 72 | 86 | Eastern Illinois (314) | Final | W | 14 |
| 26 | 2021-02-11 | Eastern Illinois (314) | 64 | 76 | Jacksonville State (227) | Final | L | -12 |
| 27 | 2021-02-13 | Eastern Illinois (314) | 67 | 80 | Tennessee Tech (310) | Final | L | -13 |
| 28 | 2021-02-18 | Eastern Illinois (314) | 68 | 59 | Murray State (116) | Final | W | 9 |
| 29 | 2021-02-20 | Eastern Illinois (314) | 76 | 69 | Austin Peay (138) | Final | W | 7 |
| 30 | 2021-02-25 | Southeast Missouri State (226) | 94 | 88 | Eastern Illinois (314) | Final | L | -6 |
| 31 | 2021-02-27 | Tennessee-Martin (205) | 73 | 68 | Eastern Illinois (314) | Final | L | -5 |