Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2016-09-04 | Notre Dame (11) | 47 | Texas (66) | 50 | Final/2OT | L | -3 |
| 2 | 2016-09-10 | Nevada (93) | 10 | Notre Dame (11) | 39 | Final | W | 29 |
| 3 | 2016-09-17 | Michigan State (5) | 36 | Notre Dame (11) | 28 | Final | L | -8 |
| 4 | 2016-09-24 | Duke (111) | 38 | Notre Dame (77) | 35 | Final | L | -3 |
| 5 | 2016-10-01 | Notre Dame (96) | 50 | Syracuse (76) | 33 | Final | W | 17 |
| 6 | 2016-10-08 | Notre Dame | 3 | North Carolina State | 10 | Final | L | -7 |
| 7 | 2016-10-15 | Stanford (27) | 17 | Notre Dame (92) | 10 | Final | L | -7 |
| 8 | 2016-10-29 | Miami (37) | 27 | Notre Dame (99) | 30 | Final | W | 3 |
| 9 | 2016-11-05 | Notre Dame (82) | 27 | Navy (40) | 28 | Final | L | -1 |
| 10 | 2016-11-12 | Army (79) | 6 | Notre Dame (86) | 44 | Final | W | 38 |
| 11 | 2016-11-19 | Virginia Tech (31) | 34 | Notre Dame (73) | 31 | Final | L | -3 |
| 12 | 2016-11-26 | Notre Dame (71) | 27 | USC (13) | 45 | Final | L | -18 |