Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2016-09-03 | Western Carolina | 7 | East Carolina | 52 | Final | W | 45 |
| 2 | 2016-09-10 | North Carolina State | 30 | East Carolina | 33 | Final | W | 3 |
| 3 | 2016-09-17 | East Carolina (79) | 15 | South Carolina (89) | 20 | Final | L | -5 |
| 4 | 2016-09-24 | East Carolina (51) | 17 | Virginia Tech (43) | 54 | Final | L | -37 |
| 5 | 2016-10-01 | Central Florida | 47 | East Carolina | 29 | Final | L | -18 |
| 6 | 2016-10-08 | East Carolina | 22 | South Florida | 38 | Final | L | -16 |
| 7 | 2016-10-13 | Navy (24) | 0 | East Carolina (90) | 0 | Postponed | - | - |
| 8 | 2016-10-22 | East Carolina (92) | 19 | Cincinnati (85) | 31 | Final | L | -12 |
| 9 | 2016-10-29 | Connecticut | 3 | East Carolina | 41 | Final | W | 38 |
| 10 | 2016-11-05 | East Carolina (92) | 24 | Tulsa (33) | 45 | Final | L | -21 |
| 11 | 2016-11-12 | SMU (82) | 55 | East Carolina (94) | 31 | Final | L | -24 |
| 12 | 2016-11-19 | Navy (30) | 66 | East Carolina (102) | 31 | Final | L | -35 |
| 13 | 2016-11-26 | East Carolina (106) | 10 | Temple (37) | 37 | Final | L | -27 |