Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2022-09-03 | Murray State (182) | 10 | Texas Tech (51) | 63 | Final | W | 53 |
| 2 | 2022-09-10 | Houston (17) | 30 | Texas Tech (51) | 33 | Final(OT) | W | 3 |
| 3 | 2022-09-17 | Texas Tech (46) | 14 | North Carolina State (8) | 27 | Final | L | -13 |
| 4 | 2022-09-24 | Texas (36) | 34 | Texas Tech (23) | 37 | Final(OT) | W | 3 |
| 5 | 2022-10-01 | Texas Tech (41) | 28 | Kansas State (22) | 37 | Final | L | -9 |
| 6 | 2022-10-08 | Texas Tech (39) | 31 | Oklahoma State (13) | 41 | Final | L | -10 |
| 7 | 2022-10-22 | West Virginia (76) | 10 | Texas Tech (27) | 48 | Final | W | 38 |
| 8 | 2022-10-29 | Baylor (36) | 45 | Texas Tech (46) | 17 | Final | L | -28 |
| 9 | 2022-11-05 | Texas Tech (46) | 24 | TCU (5) | 34 | Final | L | -10 |
| 10 | 2022-11-12 | Kansas (32) | 28 | Texas Tech (36) | 43 | Final | W | 15 |
| 11 | 2022-11-19 | Texas Tech (32) | 14 | Iowa State (59) | 10 | Final | W | 4 |
| 12 | 2022-11-26 | Oklahoma (46) | 48 | Texas Tech (28) | 51 | Final(OT) | W | 3 |
| 13 | 2022-12-28 | Texas Tech (26) | 42 | Ole Miss (21) | 25 | Final | W | 17 |