Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2022-09-03 | Southeast Missouri State (190) | 10 | Iowa State (34) | 42 | Final | W | 32 |
| 2 | 2022-09-10 | Iowa State (34) | 10 | Iowa (21) | 7 | Final | W | 3 |
| 3 | 2022-09-17 | Ohio (83) | 10 | Iowa State (19) | 43 | Final | W | 33 |
| 4 | 2022-09-24 | Baylor (26) | 31 | Iowa State (31) | 24 | Final | L | -7 |
| 5 | 2022-10-01 | Iowa State (48) | 11 | Kansas (6) | 14 | Final | L | -3 |
| 6 | 2022-10-08 | Kansas State (21) | 10 | Iowa State (56) | 9 | Final | L | -1 |
| 7 | 2022-10-15 | Iowa State (63) | 21 | Texas (14) | 24 | Final | L | -3 |
| 8 | 2022-10-29 | Oklahoma (31) | 27 | Iowa State (66) | 13 | Final | L | -14 |
| 9 | 2022-11-05 | West Virginia (79) | 14 | Iowa State (53) | 31 | Final | W | 17 |
| 10 | 2022-11-12 | Iowa State (57) | 14 | Oklahoma State (22) | 20 | Final | L | -6 |
| 11 | 2022-11-19 | Texas Tech (32) | 14 | Iowa State (59) | 10 | Final | L | -4 |
| 12 | 2022-11-26 | Iowa State (70) | 14 | TCU (3) | 62 | Final | L | -48 |