Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2022-09-03 | Houston (17) | 37 | UTSA (23) | 35 | Final | W | 2 |
| 2 | 2022-09-10 | Houston (17) | 30 | Texas Tech (51) | 33 | Final(OT) | L | -3 |
| 3 | 2022-09-17 | Kansas (20) | 48 | Houston (82) | 30 | Final | L | -18 |
| 4 | 2022-09-24 | Rice (80) | 27 | Houston (56) | 34 | Final | W | 7 |
| 5 | 2022-09-30 | Tulane (29) | 27 | Houston (58) | 24 | Final(OT) | L | -3 |
| 6 | 2022-10-07 | Houston (45) | 33 | Memphis (44) | 32 | Final | W | 1 |
| 7 | 2022-10-22 | Houston (49) | 38 | Navy (112) | 20 | Final | W | 18 |
| 8 | 2022-10-29 | South Florida (132) | 27 | Houston (50) | 42 | Final | W | 15 |
| 9 | 2022-11-05 | Houston (60) | 63 | SMU (50) | 77 | Final | L | -14 |
| 10 | 2022-11-12 | Temple (133) | 36 | Houston (58) | 43 | Final | W | 7 |
| 11 | 2022-11-19 | Houston (50) | 42 | East Carolina (63) | 3 | Final | W | 39 |
| 12 | 2022-11-26 | Tulsa (97) | 37 | Houston (56) | 30 | Final | L | -7 |
| 13 | 2022-12-23 | Louisiana (84) | 16 | Houston (56) | 23 | Final | W | 7 |