Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2022-09-03 | UTEP (90) | 13 | Oklahoma (9) | 45 | Final | W | 32 |
| 2 | 2022-09-10 | Kent State (89) | 3 | Oklahoma (9) | 33 | Final | W | 30 |
| 3 | 2022-09-17 | Oklahoma (15) | 49 | Nebraska (127) | 14 | Final | W | 35 |
| 4 | 2022-09-24 | Kansas State (32) | 41 | Oklahoma (33) | 34 | Final | L | -7 |
| 5 | 2022-10-01 | Oklahoma (40) | 24 | TCU (13) | 55 | Final | L | -31 |
| 6 | 2022-10-08 | Texas (20) | 49 | Oklahoma (53) | 0 | Final | L | -49 |
| 7 | 2022-10-15 | Kansas (26) | 42 | Oklahoma (35) | 52 | Final | W | 10 |
| 8 | 2022-10-29 | Oklahoma (31) | 27 | Iowa State (66) | 13 | Final | W | 14 |
| 9 | 2022-11-05 | Baylor (31) | 38 | Oklahoma (41) | 35 | Final | L | -3 |
| 10 | 2022-11-12 | Oklahoma (47) | 20 | West Virginia (71) | 23 | Final | L | -3 |
| 11 | 2022-11-19 | Oklahoma State (26) | 13 | Oklahoma (39) | 28 | Final | W | 15 |
| 12 | 2022-11-26 | Oklahoma (46) | 48 | Texas Tech (28) | 51 | Final(OT) | L | -3 |
| 13 | 2022-12-29 | Oklahoma (44) | 32 | Florida State (14) | 35 | Final | L | -3 |