Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2022-09-03 | Troy (100) | 10 | Ole Miss (12) | 28 | Final | W | 18 |
| 2 | 2022-09-10 | Central Arkansas (185) | 3 | Ole Miss (12) | 59 | Final | W | 56 |
| 3 | 2022-09-17 | Ole Miss (14) | 42 | Georgia Tech (104) | 0 | Final | W | 42 |
| 4 | 2022-09-24 | Tulsa (78) | 27 | Ole Miss (10) | 35 | Final | W | 8 |
| 5 | 2022-10-01 | Kentucky (36) | 19 | Ole Miss (5) | 22 | Final | W | 3 |
| 6 | 2022-10-08 | Ole Miss (6) | 52 | Vanderbilt (74) | 28 | Final | W | 24 |
| 7 | 2022-10-15 | Auburn (58) | 34 | Ole Miss (6) | 48 | Final | W | 14 |
| 8 | 2022-10-22 | Ole Miss (13) | 20 | LSU (15) | 45 | Final | L | -25 |
| 9 | 2022-10-29 | Ole Miss (11) | 31 | Texas A&M (87) | 28 | Final | W | 3 |
| 10 | 2022-11-12 | Alabama (6) | 30 | Ole Miss (13) | 24 | Final | L | -6 |
| 11 | 2022-11-19 | Ole Miss (18) | 27 | Arkansas (41) | 42 | Final | L | -15 |
| 12 | 2022-11-24 | Mississippi State (19) | 24 | Ole Miss (21) | 22 | Final | L | -2 |
| 13 | 2022-12-28 | Texas Tech (26) | 42 | Ole Miss (21) | 25 | Final | L | -17 |