Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2022-09-01 | Central Michigan (60) | 44 | Oklahoma State (6) | 58 | Final | W | 14 |
| 2 | 2022-09-10 | Arizona State (58) | 17 | Oklahoma State (6) | 34 | Final | W | 17 |
| 3 | 2022-09-17 | Arkansas-Pine Bluff (194) | 7 | Oklahoma State (26) | 63 | Final | W | 56 |
| 4 | 2022-10-01 | Oklahoma State (17) | 36 | Baylor (43) | 25 | Final | W | 11 |
| 5 | 2022-10-08 | Texas Tech (39) | 31 | Oklahoma State (13) | 41 | Final | W | 10 |
| 6 | 2022-10-15 | Oklahoma State (15) | 40 | TCU (7) | 43 | Final(2OT) | L | -3 |
| 7 | 2022-10-22 | Texas (19) | 34 | Oklahoma State (9) | 41 | Final | W | 7 |
| 8 | 2022-10-29 | Oklahoma State (17) | 0 | Kansas State (12) | 48 | Final | L | -48 |
| 9 | 2022-11-05 | Oklahoma State (25) | 16 | Kansas (23) | 37 | Final | L | -21 |
| 10 | 2022-11-12 | Iowa State (57) | 14 | Oklahoma State (22) | 20 | Final | W | 6 |
| 11 | 2022-11-19 | Oklahoma State (26) | 13 | Oklahoma (39) | 28 | Final | L | -15 |
| 12 | 2022-11-26 | West Virginia (67) | 24 | Oklahoma State (44) | 19 | Final | L | -5 |
| 13 | 2022-12-27 | Wisconsin (58) | 24 | Oklahoma State (40) | 17 | Final | L | -7 |