Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2022-09-03 | Murray State (182) | 10 | Texas Tech (51) | 63 | Final | L | -53 |
| 2 | 2022-09-10 | Jacksonville State (170) | 34 | Murray State (182) | 3 | Final | L | -31 |
| 3 | 2022-09-17 | Murray State (228) | 0 | Ball State (111) | 31 | Final | L | -31 |
| 4 | 2022-09-24 | Eastern Illinois (211) | 35 | Murray State (247) | 21 | Final | L | -14 |
| 5 | 2022-10-01 | Murray State (248) | 14 | Southeastern Louisiana (140) | 48 | Final | L | -34 |
| 6 | 2022-10-08 | Tennessee-Martin (166) | 45 | Murray State (252) | 16 | Final | L | -29 |
| 7 | 2022-10-15 | Murray State (253) | 17 | Austin Peay (165) | 52 | Final | L | -35 |
| 8 | 2022-10-22 | Murray State (253) | 18 | Lindenwood (180) | 33 | Final | L | -15 |
| 9 | 2022-10-29 | Tennessee State (225) | 3 | Murray State (238) | 19 | Final | W | 16 |
| 10 | 2022-11-12 | Robert Morris (260) | 9 | Murray State (241) | 27 | Final | W | 18 |
| 11 | 2022-11-19 | Murray State (244) | 22 | Southeast Missouri State (141) | 52 | Final | L | -30 |