Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2022-09-03 | Houston (17) | 37 | UTSA (23) | 35 | Final | L | -2 |
| 2 | 2022-09-10 | UTSA (23) | 41 | Army (40) | 38 | Final(OT) | W | 3 |
| 3 | 2022-09-17 | UTSA (90) | 20 | Texas (33) | 41 | Final | L | -21 |
| 4 | 2022-09-24 | Texas Southern (194) | 24 | UTSA (85) | 52 | Final | W | 28 |
| 5 | 2022-09-30 | UTSA (65) | 45 | Middle Tennessee (72) | 30 | Final | W | 15 |
| 6 | 2022-10-08 | Western Kentucky (85) | 28 | UTSA (55) | 31 | Final | W | 3 |
| 7 | 2022-10-14 | UTSA (49) | 30 | Florida International (139) | 10 | Final | W | 20 |
| 8 | 2022-10-22 | North Texas (95) | 27 | UTSA (46) | 31 | Final | W | 4 |
| 9 | 2022-11-05 | UTSA (44) | 44 | UAB (82) | 38 | Final(2OT) | W | 6 |
| 10 | 2022-11-12 | Louisiana Tech (123) | 7 | UTSA (39) | 51 | Final | W | 44 |
| 11 | 2022-11-19 | UTSA (29) | 41 | Rice (107) | 7 | Final | W | 34 |
| 12 | 2022-11-26 | UTEP (116) | 31 | UTSA (27) | 34 | Final | W | 3 |
| 13 | 2022-12-02 | North Texas (83) | 27 | UTSA (24) | 48 | Final | W | 21 |
| 14 | 2022-12-16 | UTSA (24) | 12 | Troy (23) | 18 | Final | L | -6 |