Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2022-09-04 | Florida State (74) | 24 | LSU (57) | 23 | Final | L | -1 |
| 2 | 2022-09-10 | Southern (232) | 17 | LSU (57) | 65 | Final | W | 48 |
| 3 | 2022-09-17 | Mississippi State (38) | 16 | LSU (34) | 31 | Final | W | 15 |
| 4 | 2022-09-24 | New Mexico (89) | 0 | LSU (18) | 38 | Final | W | 38 |
| 5 | 2022-10-01 | LSU (16) | 21 | Auburn (47) | 17 | Final | W | 4 |
| 6 | 2022-10-08 | Tennessee (5) | 40 | LSU (24) | 13 | Final | L | -27 |
| 7 | 2022-10-15 | LSU (21) | 45 | Florida (42) | 35 | Final | W | 10 |
| 8 | 2022-10-22 | Ole Miss (13) | 20 | LSU (15) | 45 | Final | W | 25 |
| 9 | 2022-11-05 | Alabama (7) | 31 | LSU (9) | 32 | Final(OT) | W | 1 |
| 10 | 2022-11-12 | LSU (7) | 13 | Arkansas (54) | 10 | Final | W | 3 |
| 11 | 2022-11-19 | UAB (78) | 10 | LSU (10) | 41 | Final | W | 31 |
| 12 | 2022-11-26 | LSU (14) | 23 | Texas A&M (80) | 38 | Final | L | -15 |
| 13 | 2022-12-03 | LSU (15) | 30 | Georgia (1) | 50 | Final | L | -20 |
| 14 | 2023-01-02 | LSU (15) | 63 | Purdue (43) | 7 | Final | W | 56 |