Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2022-09-03 | Southeastern Louisiana (145) | 7 | Louisiana (15) | 24 | Final | L | -17 |
| 2 | 2022-09-10 | Southeastern Louisiana (145) | 9 | Florida Atlantic (99) | 42 | Final | L | -33 |
| 3 | 2022-09-17 | Central Connecticut State (258) | 6 | Southeastern Louisiana (175) | 70 | Final | W | 64 |
| 4 | 2022-09-24 | Incarnate Word (121) | 35 | Southeastern Louisiana (144) | 41 | Final | W | 6 |
| 5 | 2022-10-01 | Murray State (248) | 14 | Southeastern Louisiana (140) | 48 | Final | W | 34 |
| 6 | 2022-10-08 | Texas A&M-Commerce (192) | 31 | Southeastern Louisiana (162) | 28 | Final | L | -3 |
| 7 | 2022-10-22 | Southeastern Louisiana (150) | 31 | Jacksonville State (155) | 14 | Final | W | 17 |
| 8 | 2022-10-29 | Southeastern Louisiana (147) | 28 | McNeese State (252) | 27 | Final | W | 1 |
| 9 | 2022-11-05 | Southeastern Louisiana (155) | 47 | Lamar (254) | 31 | Final | W | 16 |
| 10 | 2022-11-12 | Northwestern State (228) | 7 | Southeastern Louisiana (151) | 23 | Final | W | 16 |
| 11 | 2022-11-17 | Southeastern Louisiana (149) | 40 | Nicholls State (235) | 17 | Final | W | 23 |
| 12 | 2022-11-26 | Idaho (149) | 42 | Southeastern Louisiana (141) | 45 | Final | W | 3 |
| 13 | 2022-12-03 | Southeastern Louisiana (139) | 42 | Samford (119) | 48 | Final(OT) | L | -6 |