Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2022-08-27 | Jacksonville State (170) | 42 | Stephen F. Austin (148) | 17 | Final | W | 25 |
| 2 | 2022-09-03 | Davidson (181) | 17 | Jacksonville State (170) | 35 | Final | W | 18 |
| 3 | 2022-09-10 | Jacksonville State (170) | 34 | Murray State (182) | 3 | Final | W | 31 |
| 4 | 2022-09-17 | Jacksonville State (137) | 17 | Tulsa (70) | 54 | Final | L | -37 |
| 5 | 2022-09-24 | Jacksonville State (140) | 52 | Nicholls State (235) | 21 | Final | W | 31 |
| 6 | 2022-10-01 | Kennesaw State (207) | 28 | Jacksonville State (137) | 35 | Final(OT) | W | 7 |
| 7 | 2022-10-15 | Jacksonville State (138) | 47 | North Alabama (248) | 31 | Final | W | 16 |
| 8 | 2022-10-22 | Southeastern Louisiana (150) | 31 | Jacksonville State (155) | 14 | Final | L | -17 |
| 9 | 2022-10-29 | Jacksonville State (143) | 40 | Austin Peay (171) | 16 | Final | W | 24 |
| 10 | 2022-11-12 | Eastern Kentucky (159) | 17 | Jacksonville State (136) | 42 | Final | W | 25 |
| 11 | 2022-11-19 | Jacksonville State (132) | 40 | Central Arkansas (185) | 17 | Final | W | 23 |