Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2022-09-03 | McNeese State (211) | 17 | Montana State (96) | 40 | Final | L | -23 |
| 2 | 2022-09-10 | McNeese State (211) | 10 | Rice (119) | 52 | Final | L | -42 |
| 3 | 2022-09-17 | Alcorn State (212) | 30 | McNeese State (256) | 19 | Final | L | -11 |
| 4 | 2022-09-24 | Mississippi College | 17 | McNeese State (241) | 32 | Final | W | 15 |
| 5 | 2022-10-01 | McNeese State (237) | 20 | Incarnate Word (116) | 48 | Final | L | -28 |
| 6 | 2022-10-15 | Texas A&M-Commerce (184) | 40 | McNeese State (239) | 15 | Final | L | -25 |
| 7 | 2022-10-22 | McNeese State (248) | 35 | Nicholls State (231) | 40 | Final | L | -5 |
| 8 | 2022-10-29 | Southeastern Louisiana (147) | 28 | McNeese State (252) | 27 | Final | L | -1 |
| 9 | 2022-11-05 | Eastern Illinois (235) | 15 | McNeese State (238) | 29 | Final | W | 14 |
| 10 | 2022-11-12 | McNeese State (239) | 21 | Houston Christian | 10 | Final | W | 11 |
| 11 | 2022-11-19 | Lamar (256) | 20 | McNeese State (236) | 24 | Final | W | 4 |