Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2022-09-01 | Lincoln (CA) | 7 | Texas A&M-Commerce | 52 | Final | W | 45 |
| 2 | 2022-09-10 | Texas A&M-Commerce | 25 | Tennessee Tech (239) | 26 | Final | L | -1 |
| 3 | 2022-09-17 | Texas A&M-Commerce (248) | 17 | Sam Houston State (200) | 27 | Final | L | -10 |
| 4 | 2022-09-24 | North American | 3 | Texas A&M-Commerce (232) | 63 | Final | W | 60 |
| 5 | 2022-10-08 | Texas A&M-Commerce (192) | 31 | Southeastern Louisiana (162) | 28 | Final | W | 3 |
| 6 | 2022-10-15 | Texas A&M-Commerce (184) | 40 | McNeese State (239) | 15 | Final | W | 25 |
| 7 | 2022-10-22 | Houston Christian | 3 | Texas A&M-Commerce (181) | 31 | Final | W | 28 |
| 8 | 2022-10-29 | Incarnate Word (115) | 35 | Texas A&M-Commerce (187) | 7 | Final | L | -28 |
| 9 | 2022-11-05 | Northwestern State (227) | 41 | Texas A&M-Commerce (202) | 14 | Final | L | -27 |
| 10 | 2022-11-12 | Texas A&M-Commerce (212) | 10 | Nicholls State (234) | 12 | Final | L | -2 |
| 11 | 2022-11-19 | Tennessee State (223) | 22 | Texas A&M-Commerce (220) | 14 | Final | L | -8 |