Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2022-09-01 | Kennesaw State (122) | 17 | Samford (193) | 27 | Final | W | 10 |
| 2 | 2022-09-10 | Samford (193) | 0 | Georgia (1) | 33 | Final | L | -33 |
| 3 | 2022-09-17 | Samford (163) | 33 | Tennessee Tech (206) | 28 | Final | W | 5 |
| 4 | 2022-09-24 | Western Carolina (177) | 12 | Samford (146) | 35 | Final | W | 23 |
| 5 | 2022-10-01 | Samford (139) | 34 | Furman (173) | 27 | Final | W | 7 |
| 6 | 2022-10-08 | Wofford (235) | 14 | Samford (142) | 28 | Final | W | 14 |
| 7 | 2022-10-22 | Samford (139) | 55 | East Tennessee State (214) | 45 | Final | W | 10 |
| 8 | 2022-10-29 | Samford (135) | 38 | The Citadel (219) | 3 | Final | W | 35 |
| 9 | 2022-11-05 | Virginia Military (244) | 15 | Samford (133) | 34 | Final | W | 19 |
| 10 | 2022-11-12 | Samford (125) | 35 | Chattanooga (156) | 24 | Final | W | 11 |
| 11 | 2022-11-19 | Mercer (153) | 44 | Samford (124) | 50 | Final(OT) | W | 6 |
| 12 | 2022-12-03 | Southeastern Louisiana (139) | 42 | Samford (119) | 48 | Final(OT) | W | 6 |
| 13 | 2022-12-09 | Samford (119) | 9 | North Dakota State (114) | 27 | Final | L | -18 |