Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2022-09-03 | Nicholls State (162) | 7 | South Alabama (118) | 48 | Final | L | -41 |
| 2 | 2022-09-10 | Nicholls State (162) | 7 | Louisiana-Monroe (117) | 35 | Final | L | -28 |
| 3 | 2022-09-17 | Nicholls State (223) | 16 | Southeast Missouri State (143) | 42 | Final | L | -26 |
| 4 | 2022-09-24 | Jacksonville State (140) | 52 | Nicholls State (235) | 21 | Final | L | -31 |
| 5 | 2022-10-01 | Nicholls State (247) | 33 | Northwestern State (232) | 36 | Final | L | -3 |
| 6 | 2022-10-08 | Nicholls State (244) | 19 | Houston Christian | 17 | Final | W | 2 |
| 7 | 2022-10-15 | Incarnate Word (122) | 49 | Nicholls State (244) | 14 | Final | L | -35 |
| 8 | 2022-10-22 | McNeese State (248) | 35 | Nicholls State (231) | 40 | Final | W | 5 |
| 9 | 2022-10-29 | Nicholls State (246) | 17 | Lamar (256) | 24 | Final | L | -7 |
| 10 | 2022-11-12 | Texas A&M-Commerce (212) | 10 | Nicholls State (234) | 12 | Final | W | 2 |
| 11 | 2022-11-17 | Southeastern Louisiana (149) | 40 | Nicholls State (235) | 17 | Final | L | -23 |