Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2016-09-01 | Wofford | 21 | Tennessee Tech | 7 | Final | L | -14 |
| 2 | 2016-09-10 | Tennessee Tech | 41 | Austin Peay | 7 | Final | W | 34 |
| 3 | 2016-09-17 | Tennessee Tech | 27 | Mercer | 34 | Final | L | -7 |
| 4 | 2016-09-24 | Tennessee Tech | 23 | Tennessee-Martin | 44 | Final | L | -21 |
| 5 | 2016-10-01 | Eastern Kentucky | 30 | Tennessee Tech | 33 | Final/OT | W | 3 |
| 6 | 2016-10-08 | Tennessee Tech | 21 | Jacksonville State | 40 | Final | L | -19 |
| 7 | 2016-10-15 | Eastern Illinois | 30 | Tennessee Tech | 24 | Final | L | -6 |
| 8 | 2016-10-22 | Southeast Missouri State | 20 | Tennessee Tech | 21 | Final | W | 1 |
| 9 | 2016-11-05 | Tennessee Tech | 0 | Tennessee | 55 | Final | L | -55 |
| 10 | 2016-11-12 | Tennessee Tech | 44 | Tennessee State | 16 | Final | W | 28 |
| 11 | 2016-11-19 | Murray State | 19 | Tennessee Tech | 55 | Final | W | 36 |