Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2016-09-01 | Western Illinois | 38 | Eastern Illinois | 21 | Final | L | -17 |
| 2 | 2016-09-10 | Eastern Illinois | 21 | Miami (OH) | 17 | Final | W | 4 |
| 3 | 2016-09-17 | Eastern Illinois | 24 | Illinois State | 21 | Final | W | 3 |
| 4 | 2016-09-24 | Austin Peay | 35 | Eastern Illinois | 56 | Final | W | 21 |
| 5 | 2016-10-01 | Eastern Illinois | 14 | Southeast Missouri State | 21 | Final | L | -7 |
| 6 | 2016-10-08 | Tennessee State | 34 | Eastern Illinois | 35 | Final | W | 1 |
| 7 | 2016-10-15 | Eastern Illinois | 30 | Tennessee Tech | 24 | Final | W | 6 |
| 8 | 2016-10-22 | Murray State | 40 | Eastern Illinois | 38 | Final | L | -2 |
| 9 | 2016-10-29 | Eastern Illinois | 14 | Jacksonville State | 47 | Final | L | -33 |
| 10 | 2016-11-05 | Tennessee-Martin | 33 | Eastern Illinois | 17 | Final | L | -16 |
| 11 | 2016-11-19 | Eastern Illinois | 24 | Eastern Kentucky | 0 | Final | W | 24 |