Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2016-09-03 | Eastern Kentucky | 24 | Purdue | 45 | Final | L | -21 |
| 2 | 2016-09-08 | Pikeville | 14 | Eastern Kentucky | 55 | Final | W | 41 |
| 3 | 2016-09-17 | Eastern Kentucky | 14 | Ball State | 41 | Final | L | -27 |
| 4 | 2016-10-01 | Eastern Kentucky | 30 | Tennessee Tech | 33 | Final/OT | L | -3 |
| 5 | 2016-10-08 | Southeast Missouri State | 16 | Eastern Kentucky | 31 | Final | W | 15 |
| 6 | 2016-10-15 | Eastern Kentucky | 28 | Tennessee State | 35 | Final | L | -7 |
| 7 | 2016-10-22 | Jacksonville State | 24 | Eastern Kentucky | 7 | Final | L | -17 |
| 8 | 2016-10-29 | Eastern Kentucky | 3 | Tennessee-Martin | 33 | Final | L | -30 |
| 9 | 2016-11-05 | Murray State | 41 | Eastern Kentucky | 28 | Final | L | -13 |
| 10 | 2016-11-12 | Eastern Kentucky | 67 | Austin Peay | 30 | Final | W | 37 |
| 11 | 2016-11-19 | Eastern Illinois | 24 | Eastern Kentucky | 0 | Final | L | -24 |