Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2016-09-01 | Tennessee-Martin | 7 | Cincinnati | 28 | Final | L | -21 |
| 2 | 2016-09-10 | Tennessee-Martin | 36 | Hawaii | 41 | Final | L | -5 |
| 3 | 2016-09-17 | Bacone College | 6 | Tennessee-Martin | 84 | Final | W | 78 |
| 4 | 2016-09-24 | Tennessee Tech | 23 | Tennessee-Martin | 44 | Final | W | 21 |
| 5 | 2016-10-01 | Tennessee-Martin | 30 | Tennessee State | 34 | Final | L | -4 |
| 6 | 2016-10-08 | Austin Peay | 31 | Tennessee-Martin | 45 | Final | W | 14 |
| 7 | 2016-10-15 | Tennessee-Martin | 38 | Murray State | 31 | Final | W | 7 |
| 8 | 2016-10-22 | Tennessee-Martin | 6 | Georgia State | 31 | Final | L | -25 |
| 9 | 2016-10-29 | Eastern Kentucky | 3 | Tennessee-Martin | 33 | Final | W | 30 |
| 10 | 2016-11-05 | Tennessee-Martin | 33 | Eastern Illinois | 17 | Final | W | 16 |
| 11 | 2016-11-12 | Southeast Missouri State | 10 | Tennessee-Martin | 24 | Final | W | 14 |
| 12 | 2016-11-19 | Tennessee-Martin | 7 | Jacksonville State | 33 | Final | L | -26 |