Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2016-09-01 | North Alabama | 12 | Jacksonville State | 31 | Final | W | 19 |
| 2 | 2016-09-10 | Jacksonville State | 13 | LSU | 34 | Final | L | -21 |
| 3 | 2016-09-17 | Coastal Carolina | 26 | Jacksonville State | 27 | Final | W | 1 |
| 4 | 2016-09-24 | Jacksonville State | 48 | Liberty | 19 | Final | W | 29 |
| 5 | 2016-10-08 | Tennessee Tech | 21 | Jacksonville State | 40 | Final | W | 19 |
| 6 | 2016-10-15 | Austin Peay | 14 | Jacksonville State | 34 | Final | W | 20 |
| 7 | 2016-10-22 | Jacksonville State | 24 | Eastern Kentucky | 7 | Final | W | 17 |
| 8 | 2016-10-29 | Eastern Illinois | 14 | Jacksonville State | 47 | Final | W | 33 |
| 9 | 2016-11-05 | Jacksonville State | 17 | Southeast Missouri State | 10 | Final | W | 7 |
| 10 | 2016-11-12 | Jacksonville State | 33 | Murray State | 15 | Final | W | 18 |
| 11 | 2016-11-19 | Tennessee-Martin | 7 | Jacksonville State | 33 | Final | W | 26 |
| 12 | 2016-12-03 | Youngstown State | 40 | Jacksonville State | 24 | Final | L | -16 |