Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2016-09-04 | Hampton | 21 | Old Dominion | 54 | Final | W | 33 |
| 2 | 2016-09-10 | Old Dominion | 7 | Appalachian State | 31 | Final | L | -24 |
| 3 | 2016-09-17 | Old Dominion | 22 | North Carolina State | 49 | Final | L | -27 |
| 4 | 2016-09-24 | UTSA (102) | 19 | Old Dominion (120) | 33 | Final | W | 14 |
| 5 | 2016-10-01 | Old Dominion (94) | 52 | Charlotte (118) | 17 | Final | W | 35 |
| 6 | 2016-10-07 | Massachusetts | 16 | Old Dominion | 36 | Final | W | 20 |
| 7 | 2016-10-22 | Old Dominion | 24 | Western Kentucky | 59 | Final | L | -35 |
| 8 | 2016-10-29 | Old Dominion (76) | 31 | UTEP (124) | 21 | Final | W | 10 |
| 9 | 2016-11-05 | Marshall (128) | 14 | Old Dominion (74) | 38 | Final | W | 24 |
| 10 | 2016-11-12 | Southern Miss (77) | 35 | Old Dominion (67) | 51 | Final | W | 16 |
| 11 | 2016-11-19 | Old Dominion | 42 | Florida Atlantic | 24 | Final | W | 18 |
| 12 | 2016-11-26 | Florida International | 28 | Old Dominion | 42 | Final | W | 14 |
| 13 | 2016-12-23 | Eastern Michigan | 20 | Old Dominion | 24 | Final | W | 4 |