Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2016-09-01 | Appalachian State | 13 | Tennessee | 20 | Final/OT | L | -7 |
| 2 | 2016-09-10 | Old Dominion | 7 | Appalachian State | 31 | Final | W | 24 |
| 3 | 2016-09-17 | Miami | 45 | Appalachian State | 10 | Final | L | -35 |
| 4 | 2016-09-24 | Appalachian State | 45 | Akron | 38 | Final | W | 7 |
| 5 | 2016-10-01 | Georgia State | 3 | Appalachian State | 17 | Final | W | 14 |
| 6 | 2016-10-12 | Appalachian State | 24 | Louisiana | 0 | Final | W | 24 |
| 7 | 2016-10-22 | Idaho | 19 | Appalachian State | 37 | Final | W | 18 |
| 8 | 2016-10-27 | Appalachian State | 34 | Georgia Southern | 10 | Final | W | 24 |
| 9 | 2016-11-05 | Texas State | 10 | Appalachian State | 35 | Final | W | 25 |
| 10 | 2016-11-12 | Appalachian State | 24 | Troy | 28 | Final | L | -4 |
| 11 | 2016-11-19 | Louisiana-Monroe | 17 | Appalachian State | 42 | Final | W | 25 |
| 12 | 2016-11-26 | Appalachian State | 37 | New Mexico State | 7 | Final | W | 30 |
| 13 | 2016-12-17 | Appalachian State | 31 | Toledo | 28 | Final | W | 3 |