Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2016-09-03 | Southern Miss (86) | 44 | Kentucky (73) | 35 | Final | W | 9 |
| 2 | 2016-09-10 | Savannah State | 0 | Southern Miss | 56 | Final | W | 56 |
| 3 | 2016-09-17 | Troy (96) | 37 | Southern Miss (86) | 31 | Final | L | -6 |
| 4 | 2016-09-24 | Southern Miss (48) | 34 | UTEP (91) | 7 | Final | W | 27 |
| 5 | 2016-10-01 | Rice (123) | 28 | Southern Miss (35) | 44 | Final | W | 16 |
| 6 | 2016-10-08 | Southern Miss (30) | 32 | UTSA (113) | 55 | Final | L | -23 |
| 7 | 2016-10-15 | Southern Miss (63) | 10 | LSU (51) | 45 | Final | L | -35 |
| 8 | 2016-10-29 | Marshall (116) | 14 | Southern Miss (69) | 24 | Final | W | 10 |
| 9 | 2016-11-05 | Charlotte (122) | 38 | Southern Miss (63) | 27 | Final | L | -11 |
| 10 | 2016-11-12 | Southern Miss (77) | 35 | Old Dominion (67) | 51 | Final | L | -16 |
| 11 | 2016-11-19 | Southern Miss (82) | 23 | North Texas (105) | 29 | Final | L | -6 |
| 12 | 2016-11-25 | Louisiana Tech | 24 | Southern Miss | 39 | Final | W | 15 |
| 13 | 2016-12-17 | Southern Miss | 28 | Louisiana | 21 | Final | W | 7 |