Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2016-09-01 | Rice | 14 | Western Kentucky | 46 | Final | W | 32 |
| 2 | 2016-09-10 | Western Kentucky | 10 | Alabama | 38 | Final | L | -28 |
| 3 | 2016-09-17 | Western Kentucky | 31 | Miami (OH) | 24 | Final | W | 7 |
| 4 | 2016-09-24 | Vanderbilt | 31 | Western Kentucky | 30 | Final/OT | L | -1 |
| 5 | 2016-10-01 | Houston Baptist | 3 | Western Kentucky | 50 | Final | W | 47 |
| 6 | 2016-10-06 | Western Kentucky | 52 | Louisiana Tech | 55 | Final | L | -3 |
| 7 | 2016-10-15 | Western Kentucky | 44 | Middle Tennessee | 43 | Final/2OT | W | 1 |
| 8 | 2016-10-22 | Old Dominion | 24 | Western Kentucky | 59 | Final | W | 35 |
| 9 | 2016-10-29 | Western Kentucky | 52 | Florida Atlantic | 3 | Final | W | 49 |
| 10 | 2016-11-05 | Florida International | 21 | Western Kentucky | 49 | Final | W | 28 |
| 11 | 2016-11-12 | North Texas | 7 | Western Kentucky | 45 | Final | W | 38 |
| 12 | 2016-11-26 | Western Kentucky | 60 | Marshall | 6 | Final | W | 54 |
| 13 | 2016-12-03 | Louisiana Tech | 44 | Western Kentucky | 58 | Final | W | 14 |
| 14 | 2016-12-20 | Memphis | 31 | Western Kentucky | 51 | Final | W | 20 |