Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2016-09-03 | Massachusetts | 7 | Florida | 24 | Final | L | -17 |
| 2 | 2016-09-10 | Boston College | 26 | Massachusetts | 7 | Final | L | -19 |
| 3 | 2016-09-17 | Florida International | 13 | Massachusetts | 21 | Final | W | 8 |
| 4 | 2016-09-24 | Mississippi State | 47 | Massachusetts | 35 | Final | L | -12 |
| 5 | 2016-10-01 | Tulane | 31 | Massachusetts | 24 | Final | L | -7 |
| 6 | 2016-10-07 | Massachusetts | 16 | Old Dominion | 36 | Final | L | -20 |
| 7 | 2016-10-15 | Louisiana Tech | 56 | Massachusetts | 28 | Final | L | -28 |
| 8 | 2016-10-22 | Massachusetts | 28 | South Carolina | 34 | Final | L | -6 |
| 9 | 2016-10-29 | Wagner | 10 | Massachusetts | 34 | Final | W | 24 |
| 10 | 2016-11-05 | Massachusetts | 31 | Troy | 52 | Final | L | -21 |
| 11 | 2016-11-19 | Massachusetts | 9 | BYU | 51 | Final | L | -42 |
| 12 | 2016-11-26 | Massachusetts | 40 | Hawaii | 46 | Final | L | -6 |